IMG/HDR

General description
Essentially a two-file implementation of NII with data and metadata contained in IMG and HDR files respectively, the Analyze file format is one of the oldest neuroimaging file formats in use. Like NIfTI, Analyze is a format for multi-dimensional voxel (pixels with a depth dimension) data. Unlike NIfTI, there are several different flavors of Analyze data, which require different interpretation of the header fields.

Software

 * NiBabel, a Python library for neuroimaging file I/O, supports Analyze.
 * SPM, a Matlab-based neuroimaging analysis package, also has excellent support.